European Journal of Dental and Oral Health

Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials

Tue, 25 Mar 2025 00:00:00 +0100

The general objective of this work was to evaluate the IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 polymorphisms with the loss of one or more dental implants through a systematic review and meta-analysis of clinical trials. The PRISMA guidelines established for systematic reviews and meta-analyses were followed. It was carried out on randomized controlled clinical trials, epidemiological studies obtained from the MEDLINE, EMBASE, LILACS, IBECS and Cochrane databases. The initial search returned 593 results. 28 articles were selected, and we excluded 12 studies that did not describe the genetic polymorphism we were looking for related to dental implant survival. Therefore, we included 4 articles in this review. We analyzed all these different categories of genes with their respective polymorphisms (IL-1A [-889], IL-1B [+3954], IL-1B [+3953], IL-1B [-511], IL-4 [+33 ], IL-4 [-590], IL-6 [-174], IL-10 [-1082], IL-10 [-819], IL-10 [-592], IL-1 receptor antagonist [IL-1ra]), tumor necrosis factor (TNF-α [-308]). There are very few comprehensive studies that have the same methodologies and similar data analyzes to be able to compare them that include the types of SNPs altered in the gene related to reduced implant survival to perform the meta-analysis. This systematic review confirms results that are still controversial due to the limited sample size, the definition in the terminology dental implant failure not yet defined equally in all studies, and the non-homogeneous inclusion and exclusion criteria, which include race, age, smoking, occlusion trauma, and periodontal disease.

Alejandra Bono, Mabel Noemi Brunotto, Juan Carlos Ibanez, María Julia Murúa, Federico Ghirardi, Lucrecia García, Andrea Dantur

Various Benign and Pathological Lesions of Oral Cavity in Pediatric Patients

Sandhya J. Kadam, Krishna Veni Guttikonda, Bharat Ram Chowdry Guttikonda — Thu, 06 Mar 2025 00:00:00 +0100

Oral soft tissue lesions in pediatric patients can be congenital or developmental. They can be asymptomatic and are observed during routine pediatrician or dentist examinations. Some of the lesions become symptomatic and present as an acute care visit. Initial examination and treatment of acute symptoms are done by a pediatrician, and a few of them may need referral to a dentist for definitive treatment such as removal of the lesion. Some lesions are more prevalent in patients of certain ethnicities, age groups, and sex of the patient. Treatment of oral lesions in pediatric patients differs as some lesions are self-limiting, regress spontaneously, and no treatment is needed. Lesions that recur and remain persistent need further investigation, such as a biopsy, followed by cytopathology and culture sensitivity tests. Oral lesions are usually limited to the oral cavity, but bigger lesions may spread locally and out of the oral cavity, involving lymph nodes. Soft tissue lesions can be of bacterial, viral, fungal, or unknown etiology. Identifying and treating these lesions may prevent the risk of systemic involvement and immunological responses. This article provides an overview of different benign and pathological oral conditions in pediatric patients, as well as their diagnoses and management. It highlights the importance of differentiating benign and complicated conditions to guide the specific treatments.

Sandhya J. Kadam, Krishna Veni Guttikonda, Bharat Ram Chowdry Guttikonda

Trichomonas Tenax and Entamoeba Gingivalis Prevalence Among Palestinian Adults, A PCR-Based Cross-Sectional Study

Thikrayat Badrasawi, Walid Basha — Thu, 20 Feb 2025 00:00:00 +0100

Introduction: Periodontal diseases affect the tissues responsible for tooth support within the oral cavity. These conditions are directly connected to tooth loss and other general health issues like cardiovascular diseases. Microorganisms associated with periodontal diseases have been extensively studied; however, parasites like T. tenax and E. gingivalis have been the least investigated and least frequently linked to periodontitis. This research aims to study the prevalence of these parasites in the Palestinian adult community.

Materials and Methods: A cross-sectional study was designed to reveal the prevalence of both parasites. Cities to be included in the study were selected via cluster sampling. 291 saliva and plaque scraping samples were extracted from subjects who were eligible and accepted to enroll. Deoxyribonucleic acid (DNA) extraction was done, followed by Polymerase chain reaction (PCR) and agarose gel electrophoresis to detect parasite infection.

Results: After conducting DNA extraction and PCR, all samples were negative for T. tenax and E. gingivalis infection.

Conclusion: The negative results of this study were insufficient to establish the prevalence of the two parasites among Palestinian adults. Improved general and oral health may have reduced parasite prevalence. Further research is needed to identify other potential microorganisms directly linked to these oral diseases.

Thikrayat Badrasawi, Walid Basha

A Review of Platelet-Rich Fibrin Uses in Oral Surgery and Dental Implantology

Noor Mohammed Al-Noori, Maryam Ali, Mays Yasir — Mon, 03 Feb 2025 00:00:00 +0100

Platelet-rich fibrin is a healing biomaterial that can be used unaccompanied or in conjunction with bone grafts to promote hemostasis, bone development, and maturation. It has a tremendous likelihood for bone and soft tissue redevelopment and does not cause any inflammatory reactions. The platelet-rich Fibrin preparation protocol is very simple: Collection of blood in the glass tube and then directly centrifuging it without any additives, establishing fixed fibrin clots rich in platelet leucocytes and growth factors set in the fibrin. Platelet-rich fibrin advantages: it does not dissolve rapidly and is prepared at a low cost. Platelet-rich fibrin is used in almost all oral surgery and dental implant procedures because of its effect on the healing of both hard and soft tissue of the oral cavity.

Noor Mohammed Al-Noori, Maryam Ali, Mays Yasir

The Guidelines for Patient Examination Before Dental Implant: Literature Review

Mohammed Majid Abdulmunem, Mena Nabeel Ali — Sun, 02 Feb 2025 00:00:00 +0100

Loss of teeth produces profound morbidity regarding the esthetic and functional demand of the patient. The decision for the type of treatment to replace missing teeth is made by multiple replacement therapies such as removable and fixed appliances. Nowadays, Dental implants represent the best solution for such cases, however, the possibility or not of the treatment and the decision for appropriate treatment plan depends on different factors; some of which are related to the patients such as general health, presence of systemic diseases, medications that interfere with the treatment and may affect short and long term success of the dental implant, in addition to the condition of the oral cavity such as: gingival tissue, oral hygiene, type of occlusion, caries index, in addition to the condition of the planned implant site that include: available bone height and width, bone density, etc. all these factors should be assessed carefully by the oral surgeon utilizing intra and extra-oral clinical examination and radio graphical examinations by two or three-dimensional methods to reach the correct treatment plan for each case separately according to the acquired information after completing these tests. And to decide the type of treatment, number, length, and width of the implant and whether other modifications are needed such as a sinus lifting procedure, ridge splitting, or adding a bone graft.

Mohammed Majid Abdulmunem, Mena Nabeel Ali